Critical process parameters (CPPs) such as glucose must be monitored and controlled in every bioprocess in order to reach the desired product quality in the most efficient way. Still, there is a lack of tools to bring the analyzers and their results closer to the process.

This application note shows how the combination of two technologies, namely the automated sampling and sample processing system Numera and the Process Information Management System Lucullus (Lucullus PIMS), enable on-line and real-time availability of data for monitoring and control purposes. Both glucose monitoring and control are demonstrated in a CHO process and a technical experiment. 

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