The High Flow Rate Cell Disruptor

The High Flow Rate (HFR) Cell Disruptor is the premier production model in the Constant Systems lineup, designed to offer unparalleled lysis efficiency consistent with the standard CSL systems across a full range of processing pressures. The HFR delivers significantly higher flow rates than competitor products, reaching up to 150 L/hr. This capability enables rapid processing of the entire contents of production-scale fermenters or bioreactors, efficiently handling even challenging cell types without the need for prior pelleting and re-suspending.


  • Unique Disruption Mechanism: Incorporates Constant Systems’ unique disruption mechanism and precise hydraulic control system for optimal performance.
  • Digital Pressure Control: Disruption pressure is digitally set and displayed, offering a standard range of up to 40Kpsi.
  • High Flow Rate: Capable of processing up to 150 L/hr at maximum pressure, making it ideal for large-scale production needs.
  • Automatic Shutdown: Features an automatic shutdown mechanism for when the process is complete, enhancing safety and convenience.
  • Stable Pressure: Maintains consistent and stable pressure throughout the disruption cycle, ensuring uniform sample processing.
  • Versatile Configurations: Offers various configurations for inlet and outlet connections, facilitating direct integration with upstream and downstream equipment.
  • Comparable Performance: Delivers performance on par with the existing range of Constant Systems Ltd cell disruptors.
  • Material Quality: Contact materials include 316L and F51 duplex stainless steel or equivalent, EPDM, ensuring durability and compatibility with a wide range of samples.
  • Compliance and Validation: IQ/OQ documentation available upon request for compliance and validation processes.

Machine Specifications

  • Dimensions: 1650 x 900 x 1250 mm (LxWxH)
  • Weight: 875 kg
  • Accumulator Dimensions: 650 x 1700 mm
  • Accumulator Weight: 210 kg


Who to contact

Emma Craughan
Technical Sales Specialist

Make an enquiry

    The High Flow Rate Cell Disruptor is engineered for those in need of high-efficiency, large-volume cell disruption capabilities, without compromising on lysis efficiency. With its advanced features and robust design, the HFR is ideally suited for large-scale biotechnological and pharmaceutical applications, ensuring rapid processing with exceptional control and reliability.

    “we were adamant we should only have Constant Systems cell disruptors in our new building” – The Rosalind Franklin Institute

    Constant Systems. Cell disruption at a constant pressure giving 99% cell disruption with one pass.